risedronate sodium
risedronate sodium.JPG

CLINICAL USE

Treatment and prevention of post- menopausal osteoporosis (including corticosteroid induced)Paget’s disease

DOSE IN NORMAL RENAL FUNCTION

Post-menopausal osteoporosis: 5 mg daily or 35 mg weeklyPaget’s disease: 30 mg daily for 2 months

PHARMACOKINETICS

  • Molecular weight                           :305.1
  • %Protein binding                           :24
  • %Excreted unchanged in urine     : 50
  • Volume of distribution (L/kg)       :6.3
  • half-life – normal/ESRD (hrs)      :480/Increased

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : See ‘Other Information’
  • <10           : See ‘Other Information’

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
  • HD                     :Unknown dialysability. Dose as in GFR <10 mL/min
  • HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsCalcium-containing substances: avoid for 2 hours before and after administration

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

    OTHER INFORMATION

    Swallow whole with a glass of water 30 minutes before food. Sit or stand upright for 30 minutes after administrationRenal clearance is decreased by 70% in patients with creatinine clearance <30 mL/minNo data, but one paper suggests using a decreased dose when GFR< 20 mL/min.
    One paper reviewed all the information available and concluded that 50% of the recommended dose may be possible in ERF, but more trials are required, and osteomalacia and adynamic bone disease must first be excluded. Examples of use in other units in HD patients: Normal doses; 5 mg once weekly



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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